陈乃东简介
发布时间:2021-11-06
浏览次数:5041

一、个人简历

陈乃东,男,19729月出生,博士、BB贝博艾弗森官方网站大别山学者特聘教授、博士后合作导师,安徽中医药大学、安徽农业大学硕导,BB贝博艾弗森官方网站实验实训教学管理部党总副书记、副主任(主持党政全面工作)BB贝博艾弗森官方网站博士后科研工作站站长安徽省中药质量评价与品质提升重点实验室主任、安徽省中药资源保护与利用工程研究中心主任、安徽省乡村振兴中药产业协同技术服务中心主任、中药质量评价与品质提升六安市实验室主任安徽中药质量评价与品质提升科研创新团队负责人安徽省特支计划领军人才、六安市杰出人才(提名奖)、六安市拔尖人才、BB贝博艾弗森官方网站教学名师。主持国家自然基金、中央财政林业科技推广项目、安徽省重大专项等国家级、省部级项目20余项,共发表学术论文200余篇,申请专利50余项,主持/参与制定行业标准/地方标准23项。中国林下经济学会常务理事、安徽省植物学会常务理事、安徽省药学会制药工程专业委员会副主任委员、国家自然基金通讯评审专家。  

研究成果获安徽省科技进步二等奖2项、全国商业联合会科技进步特等奖1项、安徽省教学成果二等奖1项。

二、研究方向

主要研究方向:中药质量评价品质提升与中药创新药物研究。

三、代表性教科研项目

     近年来主持的代表性教科研项目

1.安徽省重点研发项目《江淮果岭三桃一梨产品高值加工与品质保持共性关键技术研究与产业化(2023n06020004), 执行期:2023-2025,经费:100万元

2. 2023年安徽省中医药科技攻关项目《霍山石斛道地性成因研究与品质提升模式构建》子课题(202303a0702005)执行期:2023-2027经费:72万元

3.《安徽省中药质量评价与品质提升科研创新团队》项目(2022AH010090)执行期:2022-2025,经费:200万元

4.安徽省科技重大专项:《霍山石斛品质提升关键技术集成示范与产业化研究》(201903a07020017)执行期:2019-2022。经费:150万元

5.央财林业科技推广项目《特色木本药材绿萼梅与元胡和地黄复合经营技术推广示范》执行期:2021-2023。经费:100万元

6.安徽省特支计划(第6批)项目执行期:2020-2022;经费:50万元

7.国家自然科学基金面上项目:《协同生物转化及其对中药药效物质基础积累的影响-以霍山石斛为例》执行期: 2016-2019;经费:62万元

8.国家自然科学基金面上项目:《基于濒危药用植物霍山石斛资源保护和利用的药材品质的影响因素研究》执行期: 2013-2016经费:210万元(含学校配套140万元)

9.安徽省级高校自然科学研究重点项目:《霍山石斛枫斗炮制机制及其品质控制方法研究执行期: 2016.1-2018.12

10. 中国博士后基金特别资助(第9批):《基于代谢调控的霍山石斛道地性成因研究(2016T90559)》执行期:2016.7-2018.6

11.中国博士后基金面上项目(55批):《霍山石斛药效物质基础积累的影响因素研究执行期:2014.4~2016.3

12.安徽省级高校自然科学研究重点项目:《黄酒酸败的关键因素及质量控制研究》执行期:2012.1-2014.12

13.六安市叶集区艾鑫增源农业发展有限责任公司产学研合作项目:《复方艾叶敷贴片生产工艺研究》执行期:2021-2024经费:60万元

14.安徽兰葹生物科技有限公司产学研合作项目《兰葹牌霍山石斛口服液生产工艺研究》执行期:2017.10-2018.6经费:20万元

15.山东博华生物科技有限责任公司产学研合作项目:《北方石斛种植模式研究》,执行期:2016-2018经费:80万元

16.安徽省斛生记生物有限公司产学研合作项目《石斛速溶粉加工工艺研究》,执行期:2022.1-2022.12经费:15万元

17.安徽安立肽生物科技有限公司产学研合作项目《一款石斛基降尿酸功效口服液研究》执行期:2023.1-2023.8经费:15万元

18.安徽大别山饮片有限公司产学研合作项目《黄精品质提升产品深加工技术研究》,执行期:2024.8-2025.7经费:95万元

19.安徽省《制药工程本科教学团队》项目,执行期:2022-2024经费:10万元

20.安徽省一流课程《天然药物化学》,执行期:2024-2026

四、科研成果

(一) 5年代表性学术论文

[1]Jing-Wen Hao, Wei-Ting Wang, Nai-Dong Chen(通讯),et al. Identification of 13 Natural Antioxidants in Green Calyx Plum Using  2 AAPH, ABTS, and FRAP-Coupled HPLC-DAD via QTOF-MS/MS[J]. Food Chemistry, 2025.(中科院1TOP期刊; IF:8.5)

[2]Ku-Ku Hao,Qi-Jin Wang,Sheng-Xiang Wei,Hua-Yang Si,Jing-Wen Hao,Nai-Fu Chen,Nai-Dong Chen(通讯),et al. Structural characterization and anti-inflammatory activity of a neutral polysaccharide from Dendrobium huoshanense C. Z. Tang et S. J. Cheng[J]. International Journal of Biological Macromolecule, 2025. (中科院1TOP期刊; IF:7.7)

[3] Jingwen Hao, Xuanxuan Fan, Naidong Chen, Nai-Dong Chen(通讯),et al. A Novel Method for the simultaneous determination of  2 flavonoids in Pteridium aquilinum via SPE combined with  3 UPLC-DAD via QAMS[J]. Journal of Food Composition and Analysis, 2025. (中科院TOP期刊; IF:4.0)

[4]Jiao Li, Wanxue Cao, Nai-Dong Chen(通讯). Selenized polysaccharides from Pteridium aquilinum : Fractionation, characterization, activities in vitro and mechanism insights[J]. International Journal of Biological Macromolecule, 2025. (中科院1TOP期刊; IF:7.7)

[5]Shao-Jun Zheng, Xiao-Yan Gao, Xiao-Han Diao, Nai-Dong Chen(通讯). Dendrobium huoshanense Improves Atherosclerosis in High-Fat-Induced ApoE  2 Mice by Regulating Gut Microbiota and Serum Metabolite Profiles[J]. Phytomedicine, 2025. (中科院1TOP期刊; IF:6.7)

[6]Sheng-Xiang WeiJie WangQi-Jin WangXiao-Yan GaoJun ChenKu-Ku Hao, Nai-Dong Chen(通讯)Xuan-Xuan FanYa-Feng Dai. One Novel C22-Diterpenoid Alkaloid From Dendrobium huoshanense and Its Primary In Vitro Bioactive Evaluation As Well As the Molecular Dynamics Simulations[J]. Chemistry & Biodive, 2025. (中科院3; IF:2.3)

[7]ShaoJun Zheng, YaQin Bu, Sheng Li, Nai-Dong Chen(通讯). Comparative studies of Pharmacokinetic and pharmacodynamics Investigation of Allopurinol and Benzbromarone in a Quail Model of Hyperuricemia[J]. Journal of Veterinary Science, 2025.  (中科院3; IF:1.5)         

[8]ShaoJun Zheng, Sheng Li, XiaoHan Diao, Nai-Dong Chen(通讯). Prunus mume alleviates hyperuricemic renal injury: Insights from network pharmacology and experimental models[J]. Biomedical Chromatography,2025. (中科院4; IF:1.8)

[9]Xiao-Han Diao, Qiang Tao,  Shao-Jun Zheng, Nai-Dong Chen(通讯). Components in Prunus mume and their targets in the alleviation of severe depression identified using network pharmacology analysis[J]. Int. Journal of Clinical Pharmacology and Therapeutics, 2025. (中科院4; IF:0.9)

[10]Lun-Bin Xia, Cun-Wu Chen, Shao-Shuai Bi, Ya-Fei Zhang, Nai-Dong Chen(通讯), Jing Feng. Structural characterization and bioactivity evaluation of a soluble polysaccharide (PCHP-1A) from Polygonatum cyrtonema Hua: antioxidant and α-glucosidase inhibitory activities [J]. Chemical and Biological Technologies in Agriculture,2025,12(2025): 48. (中科院2; IF:5.2)

[11]Wei-Ting Wang, Xuan-Xuan Fan, Nai-Dong Chen(通讯), Jing-Wen Hao, Man-Man Zhang, Zheng-Jun Xie. An ultra-high performance liquid chromatography– mass spectrometry method based on solid-phase extraction developed for the analysis of polyphenols in Prunus Mume Sieb. et Zucc[J]. Journal of AOAC INTERNATIONAL, 2025, 中科院4IF1.7

[12] Jing-Wen Hao, Nai-Dong Chen(通讯),Xuan-Xuan Fan, et al. Rapid determination of total flavonoid content, xanthine oxidase inhibitory activities, and antioxidant activity in Prunus mume by near-infrared spectroscopy[J]. Journal of pharmaceutical and biomedical analysis, 2024. (中科院3; IF:2.8).

[13] Fucheng Zhu, Jingli Dai, Zixu Yan, Qilin Xu, Menghua Ma, Nai-Dong Chen, et al. Engineering regioselectivity of glycosyltransferase for efficient polydatin synthesis[J]. Food Chemistry,2024. (中科院1TOP期刊; IF:8.5)

[14] Daoyuan Li, Hengsheng Wang, Nai-Dong Chen, Haiyang Jiang, Nai-Fu Chen. Metagenomic analysis of soil microbial communities associated with Poa alpigena Lindm in Haixin Mountain[J]. Qinghai Lake Brazilian Journal of Microbiology. 2024. (中科院4; IF:2.1)

[15]Jiao Li, Chao-Feng Qin, Nai-Dong Chen(通讯). Evaluation of antioxidant, antidiabetic and antiobesity potential of phenylpropanoids (PPs): Structure-activity relationship and insight into action mechanisms against dual digestive enzymes by comprehensive technologies[J]. Bioorganic Chemistry 146 (2024) 107290. TOP期刊;IF5.3

[16] Chao-Feng Qin, Nai-Dong Chen(通讯), Jiao Li. Detailed investigation on the polyphenols from four Dendrobium species against α-glucosidase: An integrated in vitro and in silico approach[J]. Arabian Journal of Chemistry 17 (2024) 105627. 中科院2IF6.0

[17] Dao-Yuan Li, Run Wang, Meng You, Nai-Dong Chen(通讯). The antimicrobial effect and mechanism of the Artemisia argyi essential oil against bacteria and fungus [J]. Brazilian Journal of Microbiology (2024) 55:727–735. 中科院4IF2.2

[18] Hao, Jing-Wen, Xuan-Xuan Fan, Yi-Na Li, Nai‐Dong Chen(通讯). Differentiation of Polygonatum cyrtonema Hua from different geographical origins by near-infrared spectroscopy with chemometricsl[J]. Journal of AOAC International, 2024. 中科院4IF1.913

[19]Fu-Cheng Zhu, Zi-xu Yan, Jing-Li Dai, Guo-Si Li, Qi-Lin Xu, Yun-Fen Ma, Jing-Bo Ma, Nai-Dong Chen. Improvement in organic solvent resistance of keratinase BLk by directed evolution[J]. Journal of Biotechnology 382 (2024) 37–43. 中科院2IF4.1

[20] Yong-Jun Zang, Yun-Fen Ma, Qi-Lin Xu, Guo-Si Li, Nai-Dong Chen, Xing Li, Fu-Cheng Zhu(通讯). TiCl4-mediated deoxygenative reduction of aromatic ketones to alkylarenes with ammonia borane[J]. Org. Biomol. Chem., 2024, 22, 932-939. 中科院3IF3.2

[21]Sheng Li, Nai-Dong Chen, Ya-Qin Bu, et al. Network pharmacology analysis of the renal protective effects of the bracken (Pteridium aquilinumusing experimental data obtained in an avian (Quail) hyperuricemia model[J]. International Journal of Clinical Pharmacology and Therapeutics, 2024 (1-17). 中科院4IF1.1

[22] Zheng ShaoJun, Jie Qiong, Chen NaiDong,et al. Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention[J]. European Journal of Drug Metabolism and Pharmacokinetics, 2024, 49(1):33-42. 中科院4IF1.9

[23]Zheng Shaojun, Xu Yifan, Chen Naidong,et al. Predictors for non-attainment of meropenem target concentrations when treating infections in critically ill patients[J]. International Journal of Clinical Pharmacology and Therapeutics, 2024, 62(1):1-7. 中科院4IF0.8

[24]Wei-Han Yang, Jing-Wen Hao, Nai-Dong Chen(通讯), Jiao Li. Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four Dendrobium polysaccharides and free monosaccharide by GC-MS [J]. Biomedical Chromatography, 2023. 中科院4IF1.8

[25]Hao, Jing-Wen,Nai‐Dong Chen(通讯)Liu, Xiao-Quanet al. Detection of the adulteration of Dendrobium huoshanense with Dendrobium henanense by UV-vis-shortwave near-infrared diffuse reflectance spectroscopy combined with chemometrics [J]. Journal of AOAC International, 2023. 中科院4IF1.913

[26] Xiao-Quan Liu, Chao-Feng Qin, Nai‐Dong Chen(通讯), et al. Simultaneous determination of phenols in the four main original plants of the famous traditional Chinese medicine Shihu by pressurized capillary electrochromatography[J]. RSC Advances, 2023. (中科院3IF3.9)

[27] Guo-Si Li, Fu-Cheng Zhu, Fang-Li Gu, Xin-Jian Yin, Qi-Lin Xu, Meng-Hua Ma, Li Zhu, Bao-Wei Lu, Nai-Dong Chen(通讯). Enzymatic Preparation of L-Malate in a Reaction System with Product Separation and Enzyme Recycling [J].Catalysts, 2022. (中科院3IF4.501) 

[28]An-Ling Zhu, Jing-Wen Hao, Lei Liu, Qi Wang, Nai-Dong Chen(通讯),  Guang-Lin Wang. Simultaneous Quantification of 11 Phenolic Compounds and Consistency Evaluation in Four Dendrobium Species Used as Ingredients of the Traditional Chinese Medicine Shihu[J]. Frontiiers in Nutrition,  2021. TOP期刊; IF:6.576

[29]Jing-Wen Hao, Xiao-Quan Liu, Nai-dong Chen(通讯), et al. Simultaneous analysis of 20 free amino acids by a single marker combined with an HPLC fingerprint evaluation of Dendrobium huoshanense[J].Journal of Food Science,2021. (中科院2IF3.167)

[30]Jing-Wen Hao, An-Ling Zhu, Nai-Dong Chen (通讯), et al. Simultaneous determination of 16 important biologically active phytohormones in Dendrobium huoshanese by PCE Electrochromatography[J]. Journal of Chromatography B, 2021. (中科院3IF3.205) 

[31]Jing-Wen Hao, Xiao-Quan Liu, Nai-Dong Chen(通讯), et al. Solid-phase extraction followed by direct TOF-MS-MS and HPLC analysis of ptaquiloside in Pteridium aquilinum from different places of China [J]. Journal of Food Composition and Analysis, 2021. (中科院2IF4.556)

[32]Jing-Wen Hao, An-Ling Zhu, Nai-Dong Chen(通讯), et al. Rapid detection of adulteration in Dendrobium huoshanense with Dendrobium henanense by ATR-FTIR combined with multivariate methods[J]. Iranian Journal of Pharmaceutical Research, 2021.(中科院4; IF:1.696)  

(二)代表性授权专利

[1]2025年授权发明专利《一种中性多糖及其制备方法和应用》,第1发明人

[2]2024年授权发明专利《一种快速预测蕨菜中总黄酮含量的方法》,第1发明人.

[3] 2023年授权发明专利《一种蕨菜中原蕨苷的分离纯化制备方法1发明人

[4] 2022年授权发明专利《一种蕨菜中原蕨苷含量的检测方法1发明人

[5]2021年授权发明专利《一种利用微生物转化山奈酚生产紫云英苷的方法》,第1发明人

(三)代表性标准

[1]国家林业团体标准《霍山石斛主要病虫害综合防控技术规程(T/CSF 0104-2024), 1

[2]国家林业团体标准《棚式栽培灵芝主要病虫害防控技术规程(T/CSF0105-2024), 1

[3]国家林业团体标准《冻干猕猴桃脆片加工技术规程(T/CSF0106-2024), 1

[4]国家林业团体标准《铁皮石斛花加工技术规程(T/CSF0107-2024), 1

[5]国家林业团体标准《灵芝中总多糖、总三萜和水分的红外光谱法快速测定技术规程(T/CSF0107-2024), 1

[6]国家林业团体标准《绿萼梅栽培技术规程》(T/CSF 0096-2024), 1

[7]国家林业团体标准《绿萼梅苗木繁育技术规程》(T/CSF 0097-2024), 1

[8]国家林业团体标准《绿萼梅幼林地复合种植元胡地黄技术规程》(T/CSF 0098-2024), 1

[9]国家林业团体标准《霍山石斛叶茶加工技术规程》( T/CSF 0099-2024) , 1

[10]国家林业团体标准《蕨菜干》( T/CSF 0100-2024), 1

[11]安徽地方标准《霍山石斛枫斗质量检测技术规程》(DB34/T 2938-2017),1

[12]安徽地方标准《霍山铁皮石斛枫斗质量检测技术规程》(DB34/T 2937-2017),1

(四)代表性中药新品种

[1]中药新品种《霍山石斛3号》(皖品鉴登字第1406003),6

[2]中药新品种《霍山石斛4号》(皖品鉴登字第1406004),7

(五)代表性成果鉴定

[1]省级成果鉴定《霍山石斛品质提升关键技术集成示范与产业化研究》1

[2]省级成果鉴定《霍山石斛枫斗炮制工艺条件及炮制过程中品质控制方法研究》,1

[3]省级成果鉴定《霍山石斛,铁皮石斛与河南石斛花茶多级红外光谱快速鉴定研究》1

、近年来获市厅级以上奖励情况

12021年省科技进步二等奖《大别山林药复合经营关键技术及集成示范研究》第1完成人

22020年获评安徽省特支计划领军才授予单位安徽省委组织部

32023年获首批六安市杰出人才(提名奖)”授予单位:中共六安市委员会

42021年获批六安市拔尖人才授予单位:六安市人社局

52022年省教学成果二等多措并举、研学融合,培养应用型制药人才》第1完成人

六、指导研究生情况

硕士生在读23人,指导已毕业12在站博士后1名。

七、联系方式   

电话0564-3305899邮箱:2004cnd@163.com